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Non human primate models

Selected publications

Mercodia assays have been used with NHP samples for many years. Below is a list of some of these groups, as well as the Mercodia assays used in the highlighted publications.  Click on the hyperlinks to view the abstracts.

Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys
Wake Forest University
Proinsulin, Insulin, C-Peptide & OxLDL

Proof of mechanism and PK and PD relationship study in cynomolgus monkeys
Pfizer, Covance & University of Birmingham
Insulin

In vivo Imaging of Autologous Islet Grafts in the Liver and Under the Kidney Capsule in Non-Human Primates
Harvard, Mass. Gen. Hospital & Joslin Diabetes Center
Insulin

Effect of a PPARa agonist on plasmalipids, lipoproteins, and glycemic control in diabetic monkeys
Wake Forest University & Pfizer
Insulin & C-Peptide

Collaborative Studies

Mercodia worked with a prominent scientist in the metabolic field to validate our insulin, C-peptide and proinsulin assays with NHP samples. This was important because the assays were originally optimized for human samples and there can be various aspects of a different sample type (e.g., sequence homology, matrix effects, etc.) that can negatively affect assay results.  

The original data from this collaboration was presented at the 2009 IPITA meeting.
Validation results with NHP samples included:

  • Excellent precision
  • No matrix interference
  • Highly accurate
  • Choice assays for IVGTT studies in NHP models